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BIOQUANT OSTEO

The BIOQUANT OSTEO software enables cutting-edge bone biology research in animal models. It supports both high-throughput automation and precise manual interaction for ASBMR standard bone histomorphometry. Unique tools simplify skeletal phenotyping, arthritis model assessment, help characterize cancer metastasis, aid in forensic anthropology, and quantify implant osseointegration.

BIOQUANT OSTEO 12.1
Proliferation Has Begun

Recent BIOQUANT OSTEO Citations

  • Inactivation of a Novel FGF23 Regulator, FAM20C, Leads to Hypophosphatemic Rickets in Mice AuthorsXiaofang Wang, Suzhen Wang, Changcheng Li, Tian Gao, Ying Liu, Afsaneh Rangiani, Yao Sun, Jianjun Hao, Anne George, Yongbo Lu, Jay Groppe, Baozhi Yuan, Jian Q. Feng, Chunlin QinAbstractFamily with sequence similarity 20,-member C (FAM20C) is highly expressed in the mineralized tissues of mammals. Genetic studies showed that the loss-of-function mutations in FAM20C were associated with human lethal osteosclerotic bone dysplasia (Raine Syndrome), implying an inhibitory role of this molecule in bone formation. However, in vitro gain- and loss-of-function studies suggested that FAM20C promotes the differentiation and mineralization of mouse mesenchymal cells and odontoblasts. Recently, we generated Fam20c conditional knockout (cKO) mice in which Fam20c was globally inactivated (by crossbreeding with Sox2 ...
    Posted May 29, 2012 11:52 AM by Nathanael Reveal
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BIOQUANT LIFE SCIENCE

The BIOQUANT LIFE SCIENCE software enables cutting edge bioscience research in animal models. It supports high-throughput immunofluorescence and immunohistochemistry, stereology, densitometry, and 3D modeling. Primary applications include developmental neuroscience, traumatic brain/spinal cord injury, glaucoma, eye-movement disorders, cardiovascular disease and muscle disorders.
Learn more about BIOQUANT LIFE SCIENCE...
View the Life Science 2012 Media Kit

BIOQUANT LIFE SCIENCE 12.5

Recent BIOQUANT LIFE SCIENCE Citations

  • Gene Therapy for Muscular Dystrophy: Lessons Learned and Path Forward AuthorsJerry R. Mendell, Louise Rodino-Klapac, Zarife Sahenk, Vinod Malik, Brian K. Kaspar, Christopher M. Walker, K. Reed ClarkAbstractOur Translational Gene Therapy Center has used small molecules for exon skipping and mutation suppression and gene transfer to replace or provide surrogate genes as tools for molecular-based approaches for the treatment of muscular dystrophies. Exon skipping is targeted at the pre-mRNA level allowing one or more exons to be omitted to restore the reading frame. In Duchenne Muscular Dystrophy (DMD), clinical trials have been performed with two different oligomers, a 2′O-methyl-ribo-oligonucleoside-phosphorothioate (2′OMe) and a phosphorodiamidate morpholino (PMO). Both have demonstrated early evidence of efficacy. A second molecular approach involves suppression ...
    Posted May 22, 2012 9:36 AM by Nathanael Reveal
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BIOQUANT SCAN: Slide Scanning Solutions for Every Lab

BIOQUANT is excited to be participating in the next generation in digital imaging. Imagine being able to generate large, high resolution digital scans of all of your slides. These scans can be shared with others, archived and retrieved, and quantified with the BIOQUANT Image Analysis Software. BIOQUANT offers slide scanning options for a variety of budget needs. We also support images from external slide scanners, such as the Olympus FSX100 and Aperio ScanScope.

Click and drag to pan around. Scroll the mouse wheel to zoom in and out.
This image was captured with automatically with BIOQUANT SCAN using automatic focus and lighting correction.We've also provided a fullscreen version.
This tissue is also an example of a non-decalcified mouse proximal tibia trichrome section
prepared by BIOQUANT Research Services

Digital Research Pathology

This emerging technique allows samples to be analyzed in offices and labs away from the microscope facility and by many people simultaneously. To do this, samples (usually tissue sections or well plates) are scanned at sub-micron resolutions and stored as calibrated digital image scans on the network. 

This means that the microscope is only occupied for as long as it takes to collect the scans of the samples. In contrast, when using live imaging for analysis, the microscope and BIOQUANT are occupied for as long as it takes to collect the data.

There are many ways to image scans at different price levels and levels of functionality. BIOQUANT SCAN is an automated solution that can image up to 7 slides or a 96-welled plate at a time. The BIOQUANT Imaging Toolkit coupled with the free Microscope Image Composite Editor is a manual solution slide scanning solution.  Third party solutions such as the Aperio Slide Scanner are also supported. 

To collect data, a scientist uses a computer with the BIOQUANT LIFE SCIENCE software to retrieve and analyze the scans. This workstation is often located in an office or lab away from the microscopy facility. With a scan, BIOQUANT lets you measure at any magnification: even creating "virtual objectives" like 0.25x so you can see even the largest sections in one field of view.

You can learn more about scanning options on the digital research pathology page.

BIOQUANT COMMUNITY

Does Your Lab Have a BIOQUANT?

The BIOQUANT Community website can help you learn to use it!
  • Contact technical support for step by step help with your protocol.
  • Learn the new tools in your BIOQUANT upgrade.
  • If your lab has a maintenance plan, you can request the most recent BIOQUANT upgrade!

Instant Demos and Personal Visits

Using a web-based screen sharing application, we can provide instantaneous demonstrations of the BIOQUANT software. We can analyze your images or choose similar images from our reference library. Contact us to request a demo.

We have an active schedule of on-site presentations in the United States. Contact us to find out when we'll be near your lab next.
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