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BIOQUANT OSTEO

The BIOQUANT OSTEO software enables cutting-edge bone biology research in animal models and human biopsy. It supports both high-throughput automation and precise manual interaction for ASBMR standard bone histomorphometry in digital histology and microCT. Unique tools simplify skeletal phenotyping, characterize arthritis models, help quantify cancer metastasis, measure chondrocyte proliferation, aid in forensic anthropology, and quantify implant osseointegration. Learn more about BIOQUANT OSTEO...

BIOQUANT OSTEO 13.2

BIOQUANT OSTEO 13.2 Now Shipping!

Latest BIOQUANT OSTEO Citation

  • Antagonism of Inhibitor of Apoptosis Proteins Increases Bone Metastasis via Unexpected Osteoclast Activation AuthorsChang Yang, Jennifer L. Davis, Rong Zeng, Paras Vora, Xinming Su, Lynne I. Collins, Suwanna Vangveravong, Robert H. Mach, David Piwnica-Worms, Katherine N. Weilbaecher, Roberta Faccio, and Deborah Veis NovackAbstractInhibitor of apoptosis (IAP) proteins play a central role in many types of cancer, and IAP antagonists are in development as anticancer agents. IAP antagonists cause apoptosis in many cells, but they also activate alternative NF-κB signaling through NF-κB–inducing kinase (NIK), which regulates osteoclasts. In bone metastasis, a positive feedback loop between tumors and osteoclasts promotes tumor growth and osteolysis. We therefore tested the effect of IAP antagonists on the bone microenvironment for metastasis. In both drug-sensitive and drug-resistant tumors, growth in ...
    Posted May 1, 2013, 2:51 PM by Nathanael Reveal
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BIOQUANT LIFE SCIENCE

The BIOQUANT LIFE SCIENCE software enables cutting edge bioscience research in animal models and human biopsy. It supports high-throughput immunofluorescence and immunohistochemistry, stereology, densitometry, and 3D modeling. Primary applications include developmental neuroscience, traumatic brain/spinal cord injury, glaucoma, eye-movement disorders, cardiovascular disease and muscle disorders. Learn more about BIOQUANT LIFE SCIENCE...

BIOQUANT LIFE SCIENCE 12.5

BIOQUANT Life Science

Latest BIOQUANT LIFE SCIENCE Citation

  • Dose-dependent Toxicity of Humanized Renilla reniformis GFP (hrGFP) Limits Its Utility as a Reporter Gene in Mouse Muscle AuthorsLindsay M Wallace, Andrew Moreo, K Reed Clark, and Scott Q HarperAbstractGene therapy has historically focused on delivering protein-coding genes to target cells or tissues using a variety of vectors. In recent years, the field has expanded to include gene-silencing strategies involving delivery of noncoding inhibitory RNAs, such as short hairpin RNAs or microRNAs (miRNAs). Often called RNA interference (RNAi) triggers, these small inhibitory RNAs are difficult or impossible to visualize in living cells or tissues. To circumvent this detection problem and ensure efficient delivery in preclinical studies, vectors can be engineered to coexpress a fluorescent reporter gene to serve as a marker of transduction. In this study, we set out to optimize adeno-associated ...
    Posted May 1, 2013, 2:43 PM by Nathanael Reveal
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BIOQUANT SCAN: Slide Scanning Solutions for Every Lab

BIOQUANT is excited to be participating in the next generation in digital imaging. Imagine being able to generate large, high resolution digital scans of all of your slides. These scans can be shared with others, archived and retrieved, and quantified with the BIOQUANT Image Analysis Software. BIOQUANT offers slide scanning options for a variety of budget needs. We also support images from external slide scanners, such as the Olympus FSX100 and Aperio ScanScope.

Click and drag to pan around. Scroll the mouse wheel to zoom in and out.
This image was captured with automatically with BIOQUANT SCAN using automatic focus and lighting correction. We've also provided a fullscreen version. This tissue is also an example of a non-decalcified mouse proximal tibia trichrome section prepared by BIOQUANT Research Services

Digital Research Pathology

This emerging technique allows samples to be analyzed in offices and labs away from the microscope facility and by many people simultaneously. To do this, samples (usually tissue sections or well plates) are scanned at sub-micron resolutions and stored as calibrated digital image scans on the network. 

This means that the microscope is only occupied for as long as it takes to collect the scans of the samples. In contrast, when using live imaging for analysis, the microscope and BIOQUANT are occupied for as long as it takes to collect the data.

There are many ways to image scans at different price levels and levels of functionality. BIOQUANT SCAN is an automated solution that can image up to 7 slides or a 96-welled plate at a time. The BIOQUANT Imaging Toolkit coupled with the free Microscope Image Composite Editor is a manual solution slide scanning solution.  Third party solutions such as the Aperio Slide Scanner are also supported. 

To collect data, a scientist uses a computer with the BIOQUANT LIFE SCIENCE software to retrieve and analyze the scans. This workstation is often located in an office or lab away from the microscopy facility. With a scan, BIOQUANT lets you measure at any magnification: even creating "virtual objectives" like 0.25x so you can see even the largest sections in one field of view.

You can learn more about scanning options on the digital research pathology page.

BIOQUANT COMMUNITY

Does Your Lab Have a BIOQUANT?

The BIOQUANT Community website can help you learn to use it!
  • Contact technical support for step by step help with your protocol.
  • Learn the new tools in your BIOQUANT upgrade.
  • If your lab has a maintenance plan, you can request the most recent BIOQUANT upgrade!

Instant Demos and Personal Visits

Using a web-based screen sharing application, we can provide instantaneous demonstrations of the BIOQUANT software. We can analyze your images or choose similar images from our reference library. Contact us to request a demo.

We have an active schedule of on-site presentations in the United States. Contact us to find out when we'll be near your lab next.
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