The BIOQUANT OSTEO software enables cutting-edge bone biology research in animal models and human biopsy. It supports both high-throughput automation and precise manual interaction for ASBMR standard bone histomorphometry in digital histology and microCT. Unique tools simplify skeletal phenotyping, characterize arthritis models, help quantify cancer metastasis, measure chondrocyte proliferation, aid in forensic anthropology, and quantify implant osseointegrationLearn more about BIOQUANT OSTEO...


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  • GATA-1 Deficiency Rescues Trabecular but not Cortical Bone in OPG Deficient Mice AuthorsTomas E. Meijome, R. Adam Hooker, Ying-Hua Cheng M.D., Ph.D., Whitney Walker, Mark C. Horowitz, Robyn K. Fuchs Ph.D. and Melissa A. Kacena Ph.D.AbstractGATA-1low/low mice have an increase in megakaryocytes (MKs) and trabecular bone. The latter is thought to result from MKs directly stimulating osteoblastic bone formation while simultaneously inhibiting osteoclastogenesis. Osteoprotegerin (OPG) is known to inhibit osteoclastogenesis and OPG-/- mice have reduced trabecular and cortical bone due to increased osteoclastogenesis. Interestingly, GATA-1low/low mice have increased OPG levels. Here we sought to determine whether GATA-1 knockdown in OPG-/- mice could rescue the observed osteoporotic bone phenotype. GATA-1low/low mice were bred with OPG-/- mice and bone ...
    Posted Sep 17, 2014, 9:14 AM by David Bishop
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The BIOQUANT LIFE SCIENCE software enables cutting edge bioscience research in animal models and human biopsy. It supports high-throughput immunofluorescence and immunohistochemistry, stereology, densitometry, and 3D modeling. Primary applications include developmental neuroscience, traumatic brain/spinal cord injury, glaucoma, eye-movement disorders, cardiovascular disease and muscle disorders. Learn more about BIOQUANT LIFE SCIENCE...


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  • The effects of temperature and body size on immunological development and responsiveness in juvenile shortnose sturgeon (Acipenser brevirostrum) AuthorsAna M. Gradil, Glenda M. Wright, David J. Speare, Dorota W. Wadowska, , Sara Purcell, Mark D. FastAbstractSturgeon are an important evolutionary taxa of which little is known regarding their responses to environmental factors. Water temperature strongly influences growth in fish; however, its effect on sturgeon immune responses is unknown. The objective of this study was to assess how 2 different temperatures affect immune responses in shortnose sturgeon (Acipenser brevirostrum) relevant immune organs such as the meningeal myeloid tissue, spleen, thymus and skin. These responses were studied in 2 different sizes of same age juvenile sturgeon kept at either 11 °C or 20 °C (4 treatment groups), before and after exposure to an ectoparasitic copepod (Dichelesthium oblongum). Based ...
    Posted Aug 22, 2014, 11:34 AM by David Bishop
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