The BIOQUANT OSTEO software enables cutting-edge bone biology research in animal models and human biopsy. It supports both high-throughput automation and precise manual interaction for ASBMR standard bone histomorphometry in digital histology and microCT. Unique tools simplify skeletal phenotyping, characterize arthritis models, help quantify cancer metastasis, measure chondrocyte proliferation, aid in forensic anthropology, and quantify implant osseointegration.


Latest BIOQUANT OSTEO Citation

  • Gut-derived serotonin induced by depression promotes breast cancer bone metastasis through the RUNX2/PTHrP/RANKL pathway in mice AuthorsJian‑Chun Zong, Xing Wang, Xiang Zhou, Chen Wang, Liang Chen, Liang‑Jun Yin, Bai‑Cheng He, Zhong‑Liang DengAbstractBreast cancer metastasizes to the bone in a majority of patients with advanced disease resulting in bone destruction. The underlying mechanisms are complex, and both processes are controlled by an interaction between locally and systemically derived signals. Clinically, breast cancer patients with depression have a higher risk of bone metastasis, yet the etiology and mechanisms are yet to be elucidated. MDA‑MB‑231 breast cancer cells were used to establish a bone metastasis model by using intracardiac injection in nude mice. Chronic mild stress (CMS) was chosen as a model of depression in mice before and after inoculation ...
    Posted Nov 23, 2015, 12:20 PM by Jon Hasfjord
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The BIOQUANT LIFE SCIENCE software enables cutting edge bioscience research in animal models and human biopsy. It supports high-throughput immunofluorescence and immunohistochemistry, stereology, densitometry, and 3D modeling. Primary applications include developmental neuroscience, traumatic brain/spinal cord injury, glaucoma, eye-movement disorders, cardiovascular disease and muscle disorders.

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  • Preconditioning of the Heart Following Transmyocardial Revascularization AuthorsChartchai Kositprapa, On Topaz, Arun Samidurai, Shinji Okubo, Vigneshwar Kasirajan, Rakesh C. KukrejaAbstractTransmyocardial Laser Revascularization (TMR) is an approved treatment of end stage coronary artery disease. Explanation on how TMR improves symptoms is currently unknown although myocardial angiogenesis and denervation are considered as possible mechanisms. In this study, we investigated the potential preconditioning effect of TMR in a model of myocardial ischemia/reperfusion injury. It has been suggested that laser phototherapy causes accumulation of safe levels of ROS, which may potentially trigger protective signaling leading to accelerated healing. Considering the essential role of reactive oxygen species (ROS) in ischemic preconditioning (IPC), we hypothesized that TMR procedure could potentially trigger cardioprotection via generation of ROS. The studies were ...
    Posted Nov 23, 2015, 12:24 PM by Jon Hasfjord
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