The BIOQUANT OSTEO software enables cutting-edge bone biology research in animal models and human biopsy. It supports both high-throughput automation and precise manual interaction for ASBMR standard bone histomorphometry in digital histology and microCT. Unique tools simplify skeletal phenotyping, characterize arthritis models, help quantify cancer metastasis, measure chondrocyte proliferation, aid in forensic anthropology, and quantify implant osseointegrationLearn more about BIOQUANT OSTEO...


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  • Decreasing NF-κB Expression Enhances Odontoblastic Differentiation and Collagen Expression in Dental Pulp Stem Cells Exposed to Inflammatory Cytokines AuthorsNeda S. T. Hozhabri, M. Douglas Benson, Michael D. Vu, Rinkesh H. Patel, Rebecca M. Martinez, Fatemeh N. Nakhaie, Harry K. W. Kim, Venu G. VaranasiAbstractInflammatory response in the dental pulp can alter the collagen matrix formation by dental pulp stem cells and lead to a delay or poor healing of the pulp. This inflammatory response is mediated by cytokines, including interleukin-1β and tumor necrosis factor-α. In this study, it is hypothesized that suppressing the actions of these inflammatory cytokines by knocking down the activity of transcription factor Nuclear Factor–κB will lead to dental pulp stem cell differentiation into odontoblasts and the production of collagen. Here, the role of Nuclear Factor–κB signaling and ...
    Posted Feb 4, 2015, 2:24 PM by David Bishop
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The BIOQUANT LIFE SCIENCE software enables cutting edge bioscience research in animal models and human biopsy. It supports high-throughput immunofluorescence and immunohistochemistry, stereology, densitometry, and 3D modeling. Primary applications include developmental neuroscience, traumatic brain/spinal cord injury, glaucoma, eye-movement disorders, cardiovascular disease and muscle disorders. Learn more about BIOQUANT LIFE SCIENCE...


BIOQUANT Life Science


  • Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury AuthorsPaul W. Fisher, Yingjie Zhao, Mario C. Rico, Vicky S. Massicotte, Christine K. Wade, Judith Litvin, Geoffrey M. Bove, Steven N. Popoff, Mary F. BarbeAbstractKey clinical features of cumulative trauma disorders include pain, muscle weakness, and tissue fibrosis, although the etiology is still under investigation. Here, we characterized the temporal pattern of altered sensorimotor behaviors and inflammatory and fibrogenic processes occurring in forearm muscles and serum of young adult, female rats performing an operant, high repetition high force (HRHF) reaching and grasping task for 6, 12, or 18 weeks. Palmar mechanical sensitivity, cold temperature avoidance and spontaneous behavioral changes increased, while grip strength declined, in 18-week HRHF rats, compared to controls. Flexor digitorum muscles had increased ...
    Posted Feb 4, 2015, 2:36 PM by David Bishop
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