The BIOQUANT OSTEO software enables cutting-edge bone biology research in animal models and human biopsy. It supports both high-throughput automation and precise manual interaction for ASBMR standard bone histomorphometry in digital histology and microCT. Unique tools simplify skeletal phenotyping, characterize arthritis models, help quantify cancer metastasis, measure chondrocyte proliferation, aid in forensic anthropology, and quantify implant osseointegrationLearn more about BIOQUANT OSTEO...


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  • Genetic manipulation of the ghrelin signaling system in male mice reveals bone compartment specificity of acylated and unacylated ghrelin in the regulation of bone remodeling AuthorsPatric JD Delhanty, Martijn van der Velde, Bram CJ van der Eerden, Yuxiang Sun, Julia MM Geminn, Aart-Jan van der Lely, Roy G Smith, and Johannes PTM van LeeuwenAbstractGhrelin receptor deficient (Ghsr-/-) mice, which lack acylated ghrelin (AG) signaling, retain a metabolic response to unacylated ghrelin (UAG). Recently, we showed that Ghsr-deficiency affects bone metabolism. The aim of this study was to further establish the impact of AG and UAG on bone metabolism. We compared bone metabolism in Ghsr-/- (lacking only AG signaling) and ghrelin deficient (Ghrl-/-; both AG and UAG deficient) male mice. Ghrl-/- mice had lower cortical bone mass, while Ghsr-/- mice had lower trabecular bone mass. This demonstrates bone compartment-specific effects ...
    Posted Jul 30, 2014, 9:24 AM by David Bishop
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The BIOQUANT LIFE SCIENCE software enables cutting edge bioscience research in animal models and human biopsy. It supports high-throughput immunofluorescence and immunohistochemistry, stereology, densitometry, and 3D modeling. Primary applications include developmental neuroscience, traumatic brain/spinal cord injury, glaucoma, eye-movement disorders, cardiovascular disease and muscle disorders. Learn more about BIOQUANT LIFE SCIENCE...


BIOQUANT Life Science


  • Evidence for cFMS signaling in HIV production by brain macrophages and microglia AuthorsLindsey Gerngross, Tracy FischerAbstractCombination antiretroviral therapy (cART) has improved the longevity and quality of life for people living with HIV; however, it does not target virus that persists in long-lived cells, such as macrophages (MΦs). This allows for the development of viral reservoirs in various anatomical compartments where these cells reside, including the central nervous system (CNS), where perivascular MΦs and resident microglia constitute the principle cellular reservoir of HIV. How HIV persists in MΦs/microglia is not completely understood; however, prosurvival signaling that protects infected MΦs/microglia from apoptosis is likely important to viral persistence. Macrophage colony-stimulating factor (M-CSF) is an important factor in MΦ survival and has been implicated in HIV neuropathogenesis ...
    Posted Jul 30, 2014, 9:36 AM by David Bishop
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