The BIOQUANT OSTEO software enables cutting-edge bone biology research in animal models and human biopsy. It supports both high-throughput automation and precise manual interaction for ASBMR standard bone histomorphometry in digital histology and microCT. Unique tools simplify skeletal phenotyping, characterize arthritis models, help quantify cancer metastasis, measure chondrocyte proliferation, aid in forensic anthropology, and quantify implant osseointegration.


Latest BIOQUANT OSTEO Citation

  • C-Mpl Is Expressed on Osteoblasts and Osteoclasts and Is Important in Regulating Skeletal Homeostasis AuthorsTomas E. Meijome,Jenna T. Baughman,R. Adam Hooker,Ying-Hua Cheng,Wendy A. Ciovacco,Sanjeev M. Balamohan,Trishya L. Srinivasan,Brahmananda R. Chitteti, Pierre P. Eleniste,Mark C. Horowitz,Edward F. Srour,Angela Bruzzaniti,Robyn K. Fuchs,Melissa A. KacenaAbstractC-Mpl is the receptor for thrombopoietin (TPO), the main megakaryocyte (MK) growth factor, and c-Mpl is believed to be expressed on cells of the hematopoietic lineage. As MKs have been shown to enhance bone formation, it may be expected that mice in which c-Mpl was globally knocked out (c-Mpl-/- mice) would have decreased bone mass because they have fewer MKs. Instead, c-Mpl-/- mice have a higher bone mass than WT controls. Using ...
    Posted Sep 29, 2015, 8:08 AM by Jon Hasfjord
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The BIOQUANT LIFE SCIENCE software enables cutting edge bioscience research in animal models and human biopsy. It supports high-throughput immunofluorescence and immunohistochemistry, stereology, densitometry, and 3D modeling. Primary applications include developmental neuroscience, traumatic brain/spinal cord injury, glaucoma, eye-movement disorders, cardiovascular disease and muscle disorders.

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  • Sparing of the extraocular muscles in mdx mice with absent or reduced utrophin expression: A life span analysis AuthorsAbby A. McDonald, Sadie L. Hebert, Linda K. McLoonAbstractSparing of the extraocular muscles in muscular dystrophy is controversial. To address the potential role of utrophin in this sparing, mdx:utrophin+/− and mdx:utrophin−/− mice were examined for changes in myofiber size, central nucleation, and Pax7-positive and MyoD-positive cell density at intervals over their life span. Known to be spared in the mdx mouse, and contrary to previous reports, the extraocular muscles from both the mdx:utrophin+/− and mdx:utrophin−/− mice were also morphologically spared. In the mdx:utrophin+/− mice, which have a normal life span compared to the mdx:utrophin−/− mice, the myofibers were larger at 3 and 12 months than the wild type age ...
    Posted Sep 29, 2015, 8:15 AM by Jon Hasfjord
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